Acción Farmacológica, Biofisicoquímica y Estructura Dinámica de la Vitamina C

JUAN R DE XAMMAR ORO; M. CRISTINA DONNAMARIA

ACTA FARM. BONAERENSE

Colegio de Farmaceuticos de la Provincia de Buenos Aires

Lugar: Buenos Aires; Año: 2006 vol. 25 p. 145 - 154

0326-2383

SUMMARY. "Pharmacological Action, Biophysical-Chemistry and Dynamical Structure of Vitamin C". Vitamin C, known as ascorbic acid, is a vitamin that participates in multiple processes, such as: hormones formation, neu-rotransmitters, carnitine, conversion of cholesterol into biliary acids, increase of the iron absorption, besides its fundamental intervention in the collagen synthesis. Since it is a powerful antioxidant it is associated in degenera-tive diseases prevention, such as cataracts, different cancer types and cardiovascular diseases. It plays an impor-tant role in the reaction of immune system. Although vitamin C is a structurally well known molecule, it is little knowledge about its dynamics and structure-function relationship. In this work it is done a thorough review that tries to clarify the limits of profitable effects and risks of moderate and high dose vitamin C. It is also shown a synthesis of its biophysics-chemical properties and the dynamics of its structure in aqueous solution using results of molecular dynamics simulation."Pharmacological Action, Biophysical-Chemistry and Dynamical Structure of Vitamin C". Vitamin C, known as ascorbic acid, is a vitamin that participates in multiple processes, such as: hormones formation, neu-rotransmitters, carnitine, conversion of cholesterol into biliary acids, increase of the iron absorption, besides its fundamental intervention in the collagen synthesis. Since it is a powerful antioxidant it is associated in degenera-tive diseases prevention, such as cataracts, different cancer types and cardiovascular diseases. It plays an impor-tant role in the reaction of immune system. Although vitamin C is a structurally well known molecule, it is little knowledge about its dynamics and structure-function relationship. In this work it is done a thorough review that tries to clarify the limits of profitable effects and risks of moderate and high dose vitamin C. It is also shown a synthesis of its biophysics-chemical properties and the dynamics of its structure in aqueous solution using results of molecular dynamics simulation.