IFLYSIB   05383
INSTITUTO DE FISICA DE LIQUIDOS Y SISTEMAS BIOLOGICOS
Unidad Ejecutora - UE
artículos
Título:
Mathematical modeling of regenerative processes
Autor/es:
CHARA OSVALDO; TANAKA ELLY M; BRUSCH LUTZ
Revista:
CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY
Editorial:
ELSEVIER ACADEMIC PRESS INC
Referencias:
Lugar: Burlington, MA, Estados Unidos; Año: 2014 vol. 108 p. 283 - 317
ISSN:
0070-2153
Resumen:
In many animals, regenerative processes can replace lost body parts.
Organ and tissue regeneration consequently also hold great medical
promise. The regulation of regenerative processes is achieved through
concerted actions of multiple organizational levels of the organism,
from diffusing molecules and cellular gene expression patterns up to
tissue mechanics. Our intuition is usually not adapted well to this
degree of complexity and the quantitative aspects of the regulation of
regenerative processes remain poorly understood. One way out of this
dilemma lies in the combination of experimentation and mathematical
modeling within an iterative process of model development/refinement,
model predictions for novel experimental conditions, quantitative
experiments testing these predictions, and subsequent model refinement.
This interdisciplinary approach has already provided key insights into
smaller scale processes during embryonic development and a so-far
limited number of more complex regeneration processes. This review
discusses selected theoretical and interdisciplinary studies and is
structured along the three phases of regeneration: (1) initiation of a
regeneration response, (2) tissue patterning during regenerate growth,
(3) arresting the regeneration response. Moreover, we highlight the
opportunities provided by extensions of mathematical models from
developmental processes toward the study of related regenerative
processes.