INGEBI 02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
artículos
Título:
A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors
Autor/es:
DA SILVA E SILVA, DANIEL; SHASHIKIRAN, SANNIDHI; DOBBS, LAUREN K.; BOCARSLY, MIRIAM E.; LUDERMAN, KATHRYN D.; SIBLEY, DAVID R.; KOLB, VANESSA; RUBINSTEIN, MARCELO; ALVAREZ, VERONICA A.
Revista:
Cell Reports
Editorial:
Elsevier B.V.
Referencias:
Año: 2019 vol. 29 p. 1147 - 1163
Resumen:
Phenotypes associated with alcohol abuse are well established. Bocarsly et al. identify the upregulation of D1R functioning as an underlying mechanism. We provide direct evidence that low levels of D2Rs on striatal projection neurons heighten ethanol stimulation and drinking, despite adverse outcomes contributing to abuse liability via enhanced D1R signaling.
