Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment

PORRÁS AI, YADON ZE, ALTCHEH J, BRITTO C, CHAVES GC, FLEVAUD L, MARTINS-FILHO OA, RIBEIRO I; SCHIJMAN AG; SHIKANAI-YASUDA MA, SOSA-ESTANI S, STOBBAERTS E, ZICKER F

PLOS NEGLECTED TROPICAL DISEASES

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2015 vol. 9

1935-2735

In Chagas disease a first and critical step to address the research and development gap is to establish a consensus on the desirable product profiles in different conditions of use. To foster and inform the development of these much needed tools, PAHO, in collaboration with the Drugs for Neglected Diseases initiative (DNDi), Médecins sans Frontières (MSF), and the Special Programme for Research and Training in Tropical Diseases (TDR), convened a multidisciplinary group of experts in Rio de Janeiro, Brazil (April 2010), to review the evidence and initiate discussions. The meeting established the basis for the development of target product profiles (TPPs) for Chagas Disease at Point-of-Care Diagnosis andAssessment of Response to Treatment, which are reported in this paper.