Development and characterization of biodegradable microparticles based on natural mucoadhesive polymers and miconazole nitrate

GUILLERMO TEJADA; LAMAS, MARÍA C.; MAXIMILIANO SORTINO; DARIO LEONARDI; VERA ALVAREZ

Mar del Plata

Simposio; XVI Simposio Latinoamericano de Polímeros (SLAP 2018) y el XIV Congreso Iberoamericano de Polímeros (CIP 2018); 2018

Miconazole nitrate (MN) is an antifungal drug widely used to treat topical fungal and yeast infections. Traditional oral topical antifungal therapies have many limitations, including short contact time with the oral mucosa and the requirement to administrate various doses per day. The aim of this work was to develop and to characterize polymeric microparticulated systems loaded with MN as an alternative therapeutic system for the treatment of oral candidiasis.