The acute phase immune response involves fever, sickness behavior and an elevated metabolic rate in the subterranean rodent Ctenomys talarum

CUTRERA, ANA PAULA; LUNA, FACUNDO; ZENUTO, ROXANA R.

PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY

UNIV CHICAGO PRESS

Lugar: Chicago; Año: 2022 vol. 95 p. 183 - 199

1522-2152

The acute phase response (APR) is an induced innate response and may involve pronounced physiological and behavioral changes. One of the most common assays to study the APR involves the use of a lypopolysaccharide (LPS) from the cell wall of Gram negative bacteria. In this study, we determined the energetic costs of the APR in the subterranean rodent Ctenomys talarum, as well as the effects of the exposure to LPS on body temperature, body mass loss, and behavior in this species. Further, we monitored levels of circulating endotoxin after LPS exposure. Our results suggest that in C. talarum, the APR is energetically costly, resulting in a 14 % increase in their metabolic rate. Animals exposed to LPS experienced a short-term thermal response, weight loss and changes in their behavior that included more time spent resting and with their eyes total or partially closed. However, the magnitude of the effects of LPS exposure varied between sexes and among animals. Also, there was a clear peak in circulating endotoxin levels in plasma 3 hours post injection (h.p.i.) and a significant decrease of these levels 24 h.p.i., but peak endotoxin concentration values recorded were highly variable among animals. In light of these results, ecological determinants of immune function variation in tuco-tucos are discussed, considering the roles of pace of life, habitat and degree of pathogen exposure in these subterranean rodents.