INVESTIGADORES
GAGLIARDINO Juan Jose
convenios, asesorías y/o servicios tecnológicos
Título:
EFFECT OF A DPP-IV INHIBITOR UPON ISLET FUNCTION AND â-CELL MASS
Autor/es:
GAGLIARDINO JJ; BORELLI MI; DEL ZOTTO H; REBOLLEDO OR; MASSA ML; GARCIA ME; MAIZTEGUI B; FRANCINI F
Fecha inicio:
2010-01-01
Fecha finalización:
2011-04-30
Naturaleza de la
Producción Tecnológica:
Biológica
Campo de Aplicación:
Salud humana
Descripción:
Incretins potentiate glucose-induced insulin secretion. They can further stimulate islet neogenesis and decrease â-cell apoptosis in rats under some conditions (1, 2), being GLP-1 one of the main responsible for such effects. Administration of DPP-IV inhibitors can mimick some of these effects in animal models of diabetes as well as in people with diabetes (3).
Administration of a fructose-rich diet (F) to normal rats induces insulin resistance and impaired glucose tolerance (IGT) or diabetes, depending on the duration of the treatment (4). Administration of DPP-4 inhibitors to F-fed rats could prevent the development of IGT or diabetes.
