EFFECT OF A HYPERCALORIC DIET ON HYPOANDROGYNOUS RAT LUNG

ABALLAY, FEDERICO EMANUEL; ZELARAYAN SARMIENTO, DANIELA; SALINAS, MARYSOL; SALINAS, ELOY; RAZZETO, GABRIELA; PEREZ CHACA, MARÍA VERONICA; CIMINARI, MARIA EUGENIA; BIAGGIO, VERÓNICA SILVINA; GOMEZ, NIDIA NOEMI

San Luis

Congreso; XXXIX Reunión Anual de la Sociedad de Biología de Cuyo; 2021

Sociedad de Biología de Cuyo

Obesity is a systemic state of inflammation and oxidative stress that affects normal respiratory physiology. The mediators and mediators behind these processes are not well known yet. Even though obesity occurs more frequently in women, its effects on health are worse on men that on women. The interest on the role of sex hormones as lung function modulators has risen in the last years. The presence of androgen receptors in lung reveal that these hormones might play a key role in lung physiology. Obesity-mediated oxidative stress produced in adipose tissue is one of the main factors considered as oxidant source and inflammation mediator. The aim of this work was to study the effect of diet-induced obesity on castrated rat lung. Wistar male rats (200 ± 20 g) were separated in four groups: Control with normal diet(CoN), castrated with normal diet (KN), control with hypercaloric diet (CoOB) and castrated with hypercaloric diet (KOB) and sacrificed 30 days after castration. We analyzed different parameters catalase activity (CAT), lipid peroxidation (TBARS), expression of Catalase (CAT) and Androgen receptor (RA) and determination of triglycerides (TG), cholesterol (CL), high-density lipoproteins (HDL), urea and lactate deshidrogenase (LDH) in serum. ANOVA and Tukey test were used for statistical analyses. The results showed TBARS levels increased in KOB group compared to CoN p