Bleomycin induces oxidative stress in rat liver with androgen deficiency

ZELARAYAN SARMIENTO, DANIELA; ABALLAY, FEDERICO EMANUEL; PEREZ CHACA, MARÍA VERONICA; GOMEZ, NIDIA; CIMINARI, MARIA EUGENIA

Congreso; XXXIX Reunión Anual de la Sociedad de Biología de Cuyo; 2021

Sociedad de Biología de Cuyo

Sex is clearly a biological variable to consider in clinical research, as well as in medical practice. Testosterone deficiency is a relativelycommon condition and may negatively affect health and quality of life. Additionally, bleomycin (BLM) is a chemotherapeutic agent usedin the treatment of different types of cancers (cytotoxic), however it generate free radicals, which induce single- and double-strand breaksin DNA. Oxidative stress has been considered as a conjoint pathological mechanism, and it contributes to initiation and progression ofliver injury. The present study examines potential differences in oxidative stress parameters in control and castrated Wistar rats undertwo different BLM doses and histological change. Adult male rats were divided in six groups: 1) control (Co); 2) Co+BLM I (doses: 1,5mg/kg); 3) Co+BLM II (doses: 10 mg/kg); 4) Ca (castrated); 5) Ca+BLM I and 6) Ca+BLM II. After 40 days of treatment, rats weresacrificed. TBARS and catalase (CAT) were measured in liver. Co+BLM II was significantly higher than Co+BLM I (p