Chronic exposure to urban air pollution in Buenos Aires city induces oxidative stress and inflammation in mice olfactory bulb

FREIRE AGUSTINA; MARIANA GARCES; CACERES LOURDES; MAGNANI NATALIA; MARCHINI TIMOTEO; MARTINEFSKI, MANUELA; TRIPODI, VALERIA; BERRA ALEJANDRO; SILVIA ALVAREZ; CALABRÓ VALERIA; EVELSON PABLO

Congreso; LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2021

Previous reports indicate that central nervous system (CNS) is a target of air pollution, causing tissue damage and functional alterations. Oxidative stress and neuroinflammation have been pointed out as possible mechanisms mediating these effects. The aim of this work was to study the chronic effects of urban air pollution on mice olfactory bulb (OB), focusing on oxidative stress and inflammation markers. BALB/c 8-week-old mice were exposed to filtered air (FA, control) or urban air (UA) inside whole-body chambers, located in a highly polluted area of Bs. As. city, for up to 4 weeks. Reduced glutathione levels (GSH) were decreased by 75% after 4 w of exposure to UA (p