Glyphosate based herbicide exposure may exacerbate endometrial hyperplasia induced by cafeteria diet in adult rats

ZANARDI MV; GASTIAZORO MP; LORENZ V; GUERRERO SCHIMPF M; ALMIRÓN A; MILESI MM; ZIERAU O; VARAYOUD J; DURANDO M

Congreso; LXVI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2021

SAIC

Many lifestyle factors can predispose to the development of endometrial carcinoma (EC). Previously, in rats, we detected that: a) cafeteria diet (CAF) induced endometrial hyperplasia (EH), a precursor lesion of EC; b) exposure to glyphosate-based herbicide (GBH) altered uterine development causing EH and increased cell proliferation. In the present work we sought to evaluate whether the exposure to a low-dose of a GBH plus CAF diet might enhance the uterine morphological alterations induced by CAF diet alone. Female Wistar rats were fed from postnatal day 21 (PND21) until PND240 with: chow diet (CON) or CAF. At PND140 one group of rats feed with CAF also received GBH through food, yielding 3 experimental groups: CON; CAF; CAF+GBH. Rats were sacrificed at PND240 and serum, fat depots, and uterine samples were obtained. Data were analyzed by Kruskal?Wallis followed by Mann-Whitney post-test (p