Beneficial consequences on myocardial mitochondrial network dynamics and function of one-month oral treatment with cannabis oil to spontaneously hypertensive rats (SHR).

PEREYRA E; GODOY COTO J; CAVALLI F; GONZÁLEZ ARBELÁEZ LF; FANTINELLI JC; ARANDA MOSQUERA JO; COLMAN LERNER E; VELEZ RUEDA JO; MOSCA SM; ENNIS IL

La Plata

Congreso; Reunión anual Sociedad Argentina de Fisiología SAFIS 2021; 2021

Introduction: Recently, the component of oil cannabis CBD was found to regulate mitochondrial DNA epigenetics, biogenesis, and network dynamics. While abnormal mitochondrial function has been repeatedly linked to a wide variety of cardiovascular diseases, components of cannabis oil have proved cardioprotective, attenuating inflammatory and oxidative damage. However, the effect of cannabis oil on hypertensive cardiac hypertrophy (CH) and specially on mitochondrial function, remains elusive. Objective: To evaluate the consequences of cannabis oil on hypertrophy, mitochondrial function, and mitochondrial network dynamics in SHR hearts.Methods: Three-month old male SHR were randomized into treated (TR) and control (CR). Cannabis sativa or olive oil were orally administered for 1 month, respectively. At the end of treatment, we measured CH, mitochondrial network dynamics by qPCR, mitochondrial membrane potential by spectrofluorometry and myocardial superoxide dismutase (SOD) activity by spectrometry. Data are presented as mean±SEM. Welch?s t-test was used for statistical differences (p