THYROID HORMONES REGULATE CELL PROLIFERATION AND ANTITUMOR IMMUNITY IN MELANOMA

STERLE HA; CAYROL F; DEBERNARDI MM; GONZALEZ G; CREMASCHI GA

Virtual

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2021; 2021

SAIC, SAI, AAFE, NANOMED-AR

Melanoma (ME) is the most severe type of skin cancer and despiteimmune checkpoint inhibitors provide exceptionally durable responses,only a limited number of patients benefit from it, makingcrucial the study of new compounds for ME treatment. Thyroid hormones(TH) influence tumor progression by direct actions on cancercells, tumor microenvironment and antitumor immunity. Our first aimwas to evaluate TH effect on the proliferation of human (A375 andWM35) and mouse (B16F10 and B16F1) ME cells. We found thatphysiological levels of TH induce 15 to 35% ME cell proliferation(p