Novel effect of cannabis sativa oil on the myocardium of hypertensive rats

PEREYRA E; GODOY COTO J; GONZÁLEZ ARBELÁEZ LF; FANTINELLI JC; CAVALLI F; ARANDA MOSQUERA JO; COLMAN LERNER E; CIOCCI PARDO, A; VELEZ RUEDA JO; PINILLA OA; MOSCA SM; ENNIS IL

Buenos Aires

Congreso; Reunión anual Sociedad Argentina de Fisiología SAFIS 2020; 2020

SAFIS Argentina

Cannabis sativa oil has been used for different medical purposes like pain relief or refractory epilepsy treatment. Its main pharmacological components are Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). CBD, through the endocannabinoid-system receptors (CB1 and CB2) has cardioprotective effects against inflammatory and oxidative damage. However, the effect of THC and CBD on hypertensive cardiac hypertrophy (CH) remains unclear. In CH dysfunctional mitochondria may produce deleterious effects on heart function. Thus, we tested the hypothesis that activation of the endocannabinoid system attenuates CH and improves myocardial mitochondria function in spontaneously hypertensive rats (SHR). To this aim, 3-month old male SHR were randomized into treated (TR) (N=4) and control (CR) (N=4). Cannabis sativa oil was orally administered to TR for 1 month. Data are presented as mean±SEM and Welch?s t-test was used for statistical differences (p