HYALURONAN MODULATION BY 4 METHYLUMBELLIFERONE (4Mu) CONFERS CHEMO SENSIBILITY TO LUNG CANCER STEM CELLS

ANA BEZAZIAN; MARCO AURELIO DIAZ GUTIERREZ; PAULA ROSELLÓ; AMANDA ESCRIBANO; MARIEL FUSCO; JUAN BRAGA MENENDEZ; ESTEBAN FIORE; JUAN BAYO; MIGUEL RIZZO; MARIANA MALVICINI

Congreso; AACR Annual Meeting 2021; 2021

Non small cell lung carcinoma( is the most common causeof cancer death worldwide 1Chemotherapy with a platinum ortaxane based drug is one of the firstline regimens for the treatment ofNSCLC However, the majority ofpatients will ultimately progress orrelapse⮚Tumor microenvironment (conformed by cancer cells coexisting with others cellular and noncellular components that driveseveral tumor processes includingchemotherapy resistance 2⮚Cancer stem cells ( are tumorinitiating cells with the capacity toform ?residual cell niches? involvedin post treatment relapse 3 CSCs arealso identified by the expression ofmarkers and CD 133 is one of themost studied CSC markers in NSCLC 4⮚Several reports have described howthe glycan hyaluronan ( a keycomponent of the tumormicroenvironment synthesized byHA synthases 5 regulates CSCfunction HA is involved in promotingCSC phenotype and self renewal 6and we have demonstrated that 4Methylumbelliferone 4 Mu), amodulator of HA synthesis, reducesCSC properties in hepatocellularcarcinoma 7AIMS