CHRONIC EXPOSURE TO URBAN AIR POLLUTION IN BUENOS AIRES CITY INDUCES OXIDATIVE STRESS AND INFLAMMATION IN MICE OLFACTORY BULB.

FREIRE AGUSTINA; MARIANA GARCES; MAGNANI NATALIA; CACERES LOURDES; MARCHINI TIMOTEO; NAHUEL MENDEZ; BERDASCO CLARA; MARTINEFSKI, MANUELA; BUCHHOLZ BRUNO; TRIPODI, VALERIA; GOLDSTEIN JORGE; GELPI RICARDO; BERRA ALEJANDRO; ALVAREZ, SILVIA; CALABRÓ VALERIA; EVELSON PABLO

Congreso; V International Congress in Translational Medicine; 2021

Previous reports indicate that the central nervous system (CNS) is a target of air pollution, causing tissue damage and functional alterations. Oxidative stress and neuroinflammation have been pointed out as possible mechanisms mediating these effects. The aim of this work was to study the chronic effects of urban air pollution on mice olfactory bulb (OB), focusing on oxidative stress markers, and mitochondrial function. Male 8-week-old BALB/c mice were exposed to filtered air (FA, control) or urban air (UA) inside whole-body exposure chambers, located in a highly polluted area of Buenos Aires city, for up to 4 weeks. OB tissue redox status, assessed as GSH/GSSG ratio, was decreased by 60% after 4 weeks of exposure to UA. Superoxide dismutase (SOD) activity showed a 40% decrease after 1 week of UA exposure (p