Study of the transcriptional network regulation by TGFbeta/Smad family proteins in embryonic stem cells.

PEREZ CASTRO, CAROLINA

Capital Federal

Exposición; Exposicion Interna PAE 37075; 2010

Consorcio en Investigación de Células Madre (CICEMA)

To elucidate the molecular mechanisms underlying ES cells stemness and its relation to cell behavior we designed a novel bioinformatics algorithm to search for those genes (candidate genes) that might be under the regulation of the core transcriptional factors (Sox-2/Oct-4, Nanog) that confer stemness properties and the TGF-β/Smad pathway. At the same time, we also investigate possible correlation between these candidate genes with the ES response to hypoxia and other pathways that also control ES properties and cell behavior.