Sleep-Preparatory Behaviors Modulate Sleep Physiology in Mice

TYAN, JEAN; SOTELO, MARIA I; MARKUNAS, CHELSEA M; MORROW, JOSHUA G; EBAN-ROTHSCHILD, ADA

Philadelphia

Conferencia; Sleep 2020 - Virtual Meeting; 2021

Sleep Research Society

Prior to sleep, animals perform various sleeppreparatory behaviors, yet little is known about their contributionto sleep physiology. Sleep hygiene, which involves proper sleep preparation, is an effective treatment for insomnia in humans. The high prevalence of sleep disorders and drawbacks of availablepharmacological interventions necessitate a better understanding of the ecological and evolutionary contexts of sleep. Nest-building is a sleep-preparatory behavior performed by many species. In thisstudy, we aimed to determine whether the presence of a nest modulates sleep. Specifically, we investigated the effects of a nest on sleep/wake architecture and activity in wake-promoting neurons in mice.