Modeling the electrical activity in myelinated nerve fibers: Towards the electrophysiological validation of neuronal bridges

SOLETTA, J.H.; FELICE CJ; GOY CB; FARFÁN FD; DE MARCO NM; ALBARRACIN ANA LIA

Piriapolis

Congreso; SABI 2020 - CONGRESO ARGENTINO DE BIOINGENIERIA; 2020

When severe injuries occur in the Central or Peripheric Nervous Tissue, this often triggers events thatpermanently damage the neurological function, which leads to a reduction in the patient?s quality of life. The use of bio-materialsscaffolding to create bridges that re-establish the lost connections are promising, but currently, have limited applicability; andelectrophysiological and biological validations demand considerable time, so it is still a field being explored by many investigatorsaround the world. In this paper a simplified empirical model is proposed to describe an action potential generation an conductionthrough myelinic fibers. The model´s electrophysiological validation was performed through qualitative analysis in threeexperimental situations that call for action potential: a) sciatic nerve in frog, b) giant lateral axons and giant medial axon inearthworm, and c) infraorbital nerve in rats. Results evidence the proposed empirical model´s great versatility to the differentevoked action potentials. The proposed model could become a valuable tool to determine the percentage of functionallyconnected fibers through neural bridges made of various materia