INVESTIGADORES
ABRAHAM Gustavo Abel
congresos y reuniones científicas
Título:
Optimization of the electrospinnability conditions of biomedical polyurethanes
Autor/es:
P.C. CARACCIOLO; F. BUFFA; G.A. ABRAHAM
Lugar:
Los Cocos, Córdoba
Reunión:
Simposio; V Simposio Chileno-Argentino de Polímeros, ARCHIPOL; 2009
Institución organizadora:
Universidad Nacional de Córdoba
Resumen:
The
development of biomimetic highly-porous scaffolds is essential for
successful tissue engineering. Nanofiber-based scaffolds prepared by
electrospinning of biodegradable synthetic polymers not only mimic the
nanoscale fibrous structure of native extracellular matrix, but also its
spatial organization, facilitating cell attachment, supporting cell
growth, and regulating cell differentiation (Thomas et al., 2006).
Surprisingly,
biodegradable segmented polyurethanes (SPU) and poly(urethane urea)s
(SPUU), which can be obtained with tailored physico-chemical and
mechanical properties (Guelcher, 2008), have been only used in limited
studies as tissue-engineered nanofibrous scaffolds (Stankus et al.,
2006). Scaffolds from elastomeric polyurethanes can withstand the
action of stress and load and undergo an elastic recovery with little or
no hysteresis. Moreover, there is an increasing need for elastomeric
synthetic biodegradable materials that exhibit soft-tissue properties. This study reports the preparation of new electrospun elastomeric scaffolds from two novel polyurethanes, based on poly(e-caprolactone)
diol, hexamethylene diisocyanate (HDI), and novel aliphatic and
aromatic chain extenders containing urea or ester functional groups,
respectively, chosen because of their different composition and mechanical properties. The
electrospinning parameters such as solution properties and processing
parameters were optimized to achieve smooth, uniform bead-free fibers.
The electrospinnability and the morphology of the obtained electrospun
scaffolds were investigated and discussed.