IDIM 12530
INSTITUTO DE INVESTIGACIONES MEDICAS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ADIPOCYTES IN THE BREAST CANCER MICROENVIRONMENT: DIFFERENT TUMOR CELLS, DIFFERENT WAYS TO RESPOND
Autor/es:
FRANCISCO DAMIÁN ROSA; PALMA, A; RUBIO, MF; LIRA, MC; SOARES MACHADO, M; COSTAS, MA; BALDI, ME; MARINO, GI
Lugar:
On line
Reunión:
Congreso; LXV Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2020
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
Adipocytes are considered to be critical in the tumoral microenvironment of breast cancer. However, most studies have focused on linking obesity and cancer, ignoring changes on normal adipocytes. Therefore, we retrieved microarray data from a GEO dataset (GSE95827) to analyse transcriptional changes in 3T3-L1 adipocytes after 3 days of co-culture with MCF7 (Ad+MCF) or MDAMB-231 breast cancer cell (Ad+MDA).By GEO2R tool, we determined 245 up-regulated genes in Ad+MCF7 and 215 in Ad+MDA compared to adipocytes alone (p
