Assessment of jawbone microarchitecture in bisphosphonate-treated sheep by cone-beam computed tomography

AVENDAÑO, MARIA EUGENIA; POLETTO, ADRIANA; ZENI, SUSANA NOEMI

Congreso; Reunión Anual de Sociedades de Biociencia; 2020

The CBCT is a non-invasive 3D reconstruction technique that enables to assess jawbone micro-architecture. It is used to illustrate results through 3D images. In the present report, the combination of CBCT with other techniques was used to evaluate changes in composition and micro-architectural structure quantity of the ewe jawbone after oestrogen withdrawal (OVX) and/or chronic treatment with high doses of zoledronic acid (zol). Three groups of adult Corriedale ewes, 35 to 40 kg body weight were used: OVX: OVX ewes receiving saline solution; ZOL: OVX ewes treated with Zol (4 mg/month) for 28 months for high cumulative dose of ZOL in bones and SHAM: SHAM ewes receiving saline solution (control). At the end of the study, hemi-mandibles were extracted: Bone mineral density (BMD) and content (BMC) of the mandibles were evaluated ex vivo by DXA (Lunar DPX); CBCT was performed using Planmeca Promax 3D Classic. Results of micro-CT: OVX as compared to SHAM ewes significantly decreased BMC and BMD as compared to SHAM ewes (p