INVESTIGADORES
CHATTAH Ana Karina
congresos y reuniones científicas
Título:
ADVANCED SSNMR TECHNIQUES, FTIR AND XRD APPLIED TO POLYMORPHISM IN A PHARMACEUTICAL COMPOUND
Autor/es:
Y. GARRO LINCK; A.K. CHATTAH; C. ROMAÑUK; M.E. OLIVERA; R. BAGGIO; M.T. GARLAND; S.L. CUFFINI; R.H. MANZO; G.A. MONTI
Lugar:
Angra do Reis
Reunión:
Congreso; 12th NUCLEAR MAGNETIC RESONANCE USERS MEETING 3rd IBEROAMERICAN NMR MEETING; 2009
Institución organizadora:
AUREMN
Resumen:
Polymorphism has been recognized as an important element of drug development. The fluoroquinolone Ciprofloxacin (CIP) is a widely prescribed broad-spectrum oral antibiotic available in more than 100 countries and has been approved for the treatment of several types of infections. Saccharin (SAC) is one of the best known and most widely used artificial sweetening agents.  Also, it has been proposed that it could be used to improve organoleptic properties of drugs. New pharmaceutical derivatives of fluoroquinolones with SAC having sweet taste, have been recently reported. In the present work we characterize the CIP-SAC form II, which is compared with the previously reported form I . CIP-SAC (II) was successfully obtained as a single-crystal.