BEHAVIORAL MODIFICATIONS INDUCED BY KETAMINE SUBANESTHETIC DOSES INJECTED 5 TO 30 MINUTES IN THE FORCED SWIMMING TEST

GUEVARA MANUEL ALEJANDRO; MARQUEZ HERRERO SANTIAGO NICOLÁS; SANCHEZ MARIA FLORENCIA; LAFUENTE JOSÉ VICENTE; BAIARDI, GUSTAVO C.; GARGIULO PASCUAL ÁNGEL

Mendoza

Jornada; XXXVI Annual Scientific Meeting of the Cuyo Biology Society; 2019

Sociedad de Biología de Cuyo

Ketamine, by antagonizing the NMDA (N-Methyl-D-Aspartic Acid) receptors of glutamate, produces psychotomimetic effects. In previous studies we have verified the action of antagonists of this type injected intraperitoneally in behavioral tests in rats. In the present work the effect of the administration of ketamine at low doses (2.5, 5 mg/kg and saline ip) is studied in the forced swimming test, at 5 and 30 minutes. Holtzman derived rats weighing 280 to 310 g were used. This test is based on the principle of learned hopelessness, which establishes that every organism that is subjected to a stressful event that it cannot control and from which it cannot escape develops, initially, anxiety and subsequently, if the event remains in time, depression. There was a significant decrease in swimming with the dose of 2.5 mg/kg (p