EFFECT OF THE JOINT ADMINISTRATION OF KETAMINE AND FLUOXETINE IN POSITIVE CALBINDINE INTERNEURONS OF THE BASILATERAL NUCLEUS OF AMÍGDALA IN Ratus novergicus: PRELIMINARY RESULTS

GUEVARA MANUEL ALEJANDRO; VAQUERO ANDREA; FERNANDEZ DIEZ MIREYA; MARQUEZ HERRERO SANTIAGO NICOLÁS; GARCÍA MENENDEZ SEBASTIÁN; ROMANOWICZ ESTEBAN; BARRUTIETA IKER; BENGOETXEA ODRIOZOLA HARKAITZ; ORTUZAR MARKES NAIARA; BAIARDI, GUSTAVO C.; LAFUENTE JOSÉ VICENTE; GARGIULO PASCUAL ÁNGEL

San Luis

Jornada; XXXVII Reunión Científica Anual Sociedad de Biología de Cuyo; 2019

Sociedad de Biología de Cuyo

There are different pharmacological treatments for depression, limited in their effectiveness and many have very long latency periods.Current research points to NMDA antagonists as possible therapeutic targets of this disorder. The objective of this work was to assessat a behavioral level the synergistic interactions between the antidepressant of the SSRIs group fluoxetine, and ketamine, a noncompetitive NMDA receptor antagonist and correlate the findings with structural changes in the basolateral nucleus of the tonsil withrespect to positive calbindin Interneurons. Holtzman rats that were treated with fluoxetine were used. 10, 15 and 20 mg / kg andketamine. 2.5, 5 and 10 mg / kg and subsequently were evaluated in the forced swim test each group consisted of n = 20. Fluoxetine indoses of 10 and 15 mg / kg and ketamine in doses of 2.5 and 5 mg / kg did not produce a significant decrease in immobility time, Onthe contrary, if significant decreases were observed with fluoxetine 20 mg / kg (p