KETAMINE DISRUPTS WORKING MEMORY IN AHOLE BOARD TASK

GUEVARA MANUEL; JIMENEZ BAIGORRIA LUIS; TINNIRELLO BELEN; RODRÍGUEZ JESICA; SERRANO LUCAS; LANDA ADRIANA; BAIARDI MIGUEL; GARGIULO PASCUAL

San Juan

Jornada; SEGUNDA REUNIÓN CONJUNTA DE SOCIEDADES DE BIOLOGÍA DE LA REPÚBLICA ARGENTINA; 2011

Sociedad Argentina de Biología, sociedad de biología de Cuyo, sociedad de biología de Córdoba

Ketamine, a N-methyl-D-Aspartic-acid (NMDA) receptor antagonist, is an anesthetic that has psychotogenic effects in special conditions. Since working memory deficits have been described in schizophrenia, we studied here the effects of Ketamine on this function, using a hole board test to search for a disruption in this task. Male rats derived from a Holtzman colony were used weighing 240- 270 g, divided in 5 groups (saline control, Ketamine 5, 10, 15 and 20 mg/kg, n=19-24). Locomotor activity (ambulatory, non ambulatory and vertical movements) and number of entrances to the holes were measured. A significant modification on locomotiona and holes exploration parameters was observed in the test. We conclude that Ketamine disrupts working memory within present conditions.