DELAYED EFFECT OF TRANYLCYPROMINE IN THE RAT FORCED SWIMMING TEST

MARQUEZ HERRERO SANTIAGO NICOLÁS; HERNANDEZ JOSÉ IGNACIO; CUNIETTI JOSEFINA; IRIBAS FRANCISCO; LORENZO S.; PINTO G.; ROMANOWICZ ESTEBAN; FARIAS K.; BAREA D.; FRIAS B.; GUEVARA MANUEL ALEJANDRO; GARGIULO PASCUAL ÁNGEL

Merlo, Provincia de San Luis

Congreso; XXXV Annual Scientific Meeting of the Cuyo Biology Society; 2017

Sociedad de Biología de Cuyo

Major depression is a prevalent, serious, recurrent psychiatric disorder that has been ranked by theWHO as the fourth leading cause of disability worldwide. Nowadays, the mono-amine oxidaseinhibitors are used for treating patients with treatment resistant depression. However, some authorsrefer to this group as one of the most efficient antidepressants. The aim of this investigation is toestablish the doses in which tranylcypromine has an antidepressant effect to analyzepharmacological interactions in future researches. Holtzman rats were treated with saline solution,tranylcypromine 2.5 mg/kg (T 2.5), 5 mg/kg (T 5) or 10 mg/kg (T 10) and were tested in the forcedswimming test 30 minutes later. T 10 rats showed an increased climbing time when compared tosaline, T 5 and T 2.5 (p