INHIBITORY EFFECT ON SHORT TERM MEMORY INDUCED BY SUBANESTHETIC DOSES OF KETAMINE ON NOVEL OBJECT RECOGNITION TEST IN RATS

ROMANOWICZ ESTEBAN; SANTIN CINTIA; GARCÍA MENENDEZ SEBASTIÁN; GUEVARA MANUEL ALEJANDRO; GARGIULO PASCUAL ÁNGEL

Mendoza

Jornada; XXXIV Annual Scientific Meeting of the Cuyo Biology Society; 2016

Sociedad de Biología de Cuyo

Ketamine is a dissociative anesthetic. It was derived from phencyclidine. Pharmacologically, it is a noncompetitive NMDA glutamatergic receptor blocker. It binds intracanalicularly the phencyclidine site. Given its pharmacological action, it has been used to induce animal models of schizophrenia. Within these models novel object recognition test involves variables related to memory and perception. Both variables have been previously studied by us in different models. In this study the effect of Ketamine is experimented. We used an intraperitoneal administration of ketamine in sub-anesthetic doses (1.25, 2.5 and 5 mg / kg ip) 10 min before training. Test was realized 120 min after training. The effect on novel object recognition test parameters was studied. Rats of a Holtzman derived colony weighing 240-290 g were used. We observed that the treatment produced a significant increase in total scan time in the evaluation session (p