EFFECT OF GAMMA-AMINO-BUTYRIC ACID ON ANXIETY IN THE PLUS OPEN FIELD TEST IN RATS.

GARGIULO AUGUSTO; GUEVARA MANUEL ALEJANDRO; ROMANOWICZ ESTEBAN; LANDA ADRIANA; MESONES HUMBERTO LUIS; GARGIULO PASCUAL ÁNGEL

Mendoza

Jornada; XXXIV Annual Scientific Meeting of the Cuyo Biology Society; 2016

Sociedad de Biología de Cuyo

Gamma-Amino-Butyric Acid (GABA) is a natural compound that mediates an important inhibitory effect within the Central Nervous System (CNS). It is peripherally administered in clinical medicine, but it has been proposed that it may not pass the Blood Brain Barrier (BBB). The aim of the present study is to elucidate the possibility of a central effect when administered peripherally. Male rats weighing 240-270 g from a Holtzman derived colony were used, divided in four groups. These rats were injected with saline or GABA (12.5 and 25 mg/kg) 5 min before testing. The test was the Open Field (Columbus Instruments) in the conditions of our laboratory. Classical parameters were considered: vertical movements, ambulatory movements, non ambulatory movements, and total number of movements. A significant decrease in ambulatory movements was observed with the middle dose of GABA (p