SYNERGISTIC EFFECT OF KETAMINE AND FLUOXETINE IN THE FORCED SWIMMING TEST

MARQUEZ HERRERO SANTIAGO NICOLÁS; HERNANDEZ JOSÉ IGNACIO; GARGIULO PASCUAL ÁNGEL; GUEVARA MANUEL ALEJANDRO

Mendoza

Jornada; XXXIV Annual Scientific Meeting of the Cuyo Biology Society; 2016

Sociedad de Biología de Cuyo

Major depression is a prevalent psychiatric disorder. Different pharmacological treatments have their limitations as regards their efficacy and time of latency, requiring even weeks before showing clinical effects. Recent research has shown that NMDA (N-Methyl-D-Aspartate) receptors might be involved in Major depression?s pathophysiology and therefore they are possible therapeutic targets. The present study investigates the possible synergistic interaction between NMDA antagonist Ketamine and SSRI (selective serotonin reuptake inhibitor) Fluoxetine. Holtzmann derived rats where treated with ketamine (2.5, 5 and 10 mg/kg) and fluoxetine (5, 10 and 20 mg/kg) 30 minutes before subjected to the forced swimming test. Higher doses of Fluoxetine (20 mg/kg, p