Intrinsic structural disorder on proteins is involved in the interactome evolution

UHART, MARINA; MOYANO, LUIS; MASONE, DIEGO; BUSTOS, D.M.

Congreso; 10mo Congreso de la Asociación Argentina de Bioinf y Biol Comp; 2019

 It has become evident that the generation of big amount of biological data through new sequencing technologies alone are not enough to truly understand cell complexity. Despite having identified the function of hundreds of genes many details of how exactly they contribute to cell physiology remain obscure. Understanding how cellular systems evolve on a genome-scale is central in biology and medicine. The representation of protein interaction networks in the twodimensional hyperbolic plane has been shown to be both significant and useful: node coordinates has encrypted information about protein evolution, structure, and function.