PERIPHERAL MARKERS OF OXIDATIVE STRESS AS A TOOL FOR INVESTIGATE NEUROLOGICAL PATIENTS.

REPETTO, MARISA; LLESUY, SUSANA

Buenos Aires, Argentina

Congreso; XIII Bienal Meeting of the Society for Free Radical Research International; 2004

Society for Free Radical Research International

Studies on central nervous systems have shown that neuronal activity leads to defined extra and intracellular ionic signaling, energetic and neurotransmitter interactions that may act as intercellular signals. The extracellular ion species in the regulation of neuronal activity by glia are: potassium, calcium and protons. Glia regulates ionic exchanges with plasma via pericapillary process and the blood-brain barrier. Blood and cerebrospinal fluid are involved in regulation of the ionic and fluid constituents of the brain.Problems exist in studying clinical evolution of patients with neurological diseases. Several studies made in human central nervous system have shown that oxidative stress participates in neurodegenerative diseases such as Alzheimer, vascular dementia, Parkinson, sclerosis lateral amyothrophic, familial amyloidotic, and neurological consequences of HIV infection, AIDS and hypothyroidism.The aim of this work was to determine if peripheral markers of oxidative stress in blood system of neurological patients may reflect intracellular events. To determine the occurrence of oxidative stress the markers evaluated in blood were: tert-butyl hydroperoxide initiated chemiluminescence, total plasma antioxidant capacity, total glutathione and antioxidant enzyme activities. Peripheral oxidative stress was observed in all the pathologies studied and peripheral markers may be used to evaluate clinical treatments and evolution of patients.