EFFECTS OF THYROXINE HORMONE ON MARKERS OF OXIDATIVE STRESS IN HYPOTHYROIDISM.

REPETTO, MARISA; ABALOVICH, MARCOS; GUTIERREZ, SILVIA; LLESUY, SUSANA

Buenos Aires, Argentina

Congreso; International Thyroid Congress; 2005

American Thyroid Society

Thyroid hormones are associated with the oxidative and antioxidant state. Markers of oxidative stress in erythrocytes of 29 SH (state II) and 15 clinical hypothyroid (CH) patients (n= 44, 5 male, 39 female, 40 ± 10 mean age) and 30 healthy euthyroid controls (C) were evaluated, before and after thyroxine therapy (T). We measured chemiluminescence (CL), total plasma antioxidant potential (TRAP), glutathione content (GSH), superoxide dismutase (SOD), catalase (Cat) and glutathione peroxidase (GPx) activities. SH and CH patients were reevaluated in the euthyroid state (E) after T treatment. In H, CL levels did not show any significantly differences between SH and C meanwhile in CH, CL were lower (45%, p