Membranes applied to guided bone tissue regeneration: Use of hydroxyapatite nanoparticles to improve their biological properties

D'ELÍA NOELIA L.; RIAL SILVA, RAMON; SARTUQUI, JAVIER; ERCOLI, DANIEL; RUSO JUAN M.; MESSINA, PAULA V.; MESTRES, GEMMA

Virtual

Encuentro; 1st Zooming into preclinical nanomedicines in the era Covid 19.; 2020

Asociación Argentina de Nanomedicinas

Guided bone tissue regeneration is widely employed, especially in the oral maxillofacial region. The main objectives of the application of a barrier membrane are: (a) covering a bone defect supporting the ingrowth of osteogenic cells without competition from other cells, and (b) preventing micromovement of the bone graft . In recent years, various membranes applied for guided bone regeneration have been developed. Among them, biodegradable membranes have the advantage to avoid a second surgical procedure to extract them and bioactive membranes ensure tight bonding of the biomaterial within the host tissue. Our research group developed a biodegradable material composed of alginate crosslinked with hydroxyapatite nanoparticles. Alginate is widely used in biomedical applications due to its clinically proved biocompatibility, while hydroxyapatite nanoparticlesstimulate osteoblast differentiation and coagulation process.