Multicentric squamous cell carcinoma in situ in a dog resembling Bowen?s disease. Veterinary Pathology

SANZ RESSEL BL, DUARTE MJ, BROGLIA GC, BARBEITO CG, MASSONE AR

Sidney

Congreso; 9th World Congress of Veterinary Dermatology; 2020

ESVD and ACVD

Multicentric squamous cell carcinoma in situ (MSCCIS)is very uncommon in dogs, with only one case reportedin the veterinary literature. We describe an 8-year-oldfemale mixed-breed dog that developed multifocal wellcircumscribed,pigmented, crusted, proliferative or erosivecutaneous lesions, measuring 0.5?3 cm in diameter.Lesions were found in pigmented and nonpigmentedskin. The most frequently affected areas were dorsalthorax, abdomen and proximal limbs. Metastasis wasnot observed. The dog was otherwise healthy.Histopathologically, lesions were characterized by wellcircumscribedareas of neoplastic keratinocytes withoutinvasion through the basement membrane into the dermis.Irregular epidermal and superficial follicularhyperplasia and dysplasia were observed. Moderateparakeratotic hyperkeratosis also was detected. Lesionson pigmented areas showed marked hyperpigmentationof the epidermis. Papillomavirus-associated cytopathiceffects in the keratinocytes were not observed. The casereported here is the second reported case of MSCCISin a dog with clinical and histological features ofBowen?s disease.