GLAUCOMA INDUCES REDOX IMBALANCE IN THE PRIMARY VISUAL CORTEX IN A RAT EXPERIMENTAL MODEL

HVOZDA ARANA, AILEN G.; LASAGNI VITAR, ROMINA M.; REIDES, CLAUDIA G.; MUÑOA, LAURA B.; TOPP, NICOLE D.; LERNER, FABIAN; FERREIRA, SANDRA M.

Buenos Aires

Congreso; Reunión de la Sociedad Argentina de Investigaciones Clínicas (SAIC); 2020

Glaucoma is the first irreversible cause of blindness worldwide and damages structures in the brain, such as the primary visual cortex. The aims were to elucidate the antioxidant enzymes activities, the intracellular sources of oxidant species (OS) and the signaling pathways involved in the redox metabolism in the primary visual cortex in an experimental glaucoma model.3-month female Wistar rats were operated by cauterizing two of the episcleral veins: glaucoma group (GG n=12); the control group (CG n=12) received a sham procedure. Seven days after surgery rats were euthanized and the primary visual cortex was dissected (CICUAL FFyB n° 3314). Antioxidant enzymes activities, GSH metabolism, NOX activity, iNOS expression, Nrf2 and NF-κB activation were evaluated.When compared to CG, GG showed 147% increase in NOX activity (p