Hospitalization for venous thromboembolic disease management: a 10 years Registry in Buenos Aires, Argentina

MARIA LOURDES POSADAS MARTINEZ

Congreso; XXVIII CONGRESO NACIONAL DE MEDICINA, SOCIEDAD ARGENTINA DE MEDICINA; 2020

Fernando Javier VazquezMaría Florencia Grande RattiMaría Elena ZapiolaDiego Hernán GiuntaMaría Lourdes Posadas MartínezAim: Venous thromboembolic disease (VTD) is the most frequent cause of preventable mortality in hospitalized patients and the third leading cause of mortality due to vascular diseases. Our aim was to describe patients with VTD who required hospitalization, their clinical characteristics, management and evolution after discharge.Methods: Prospective cohort which included patients with acute and symptomatic VTE who required hospitalization in a tertiary center (Hospital Italiano de Buenos Aires) for their management in a 10 years´ period (between 2006 and 2016). Patients were included at the time of VTD diagnosis; we collected baseline characteristics, risk stratification and initial therapeutic approach. They were periodically, prospectively and systematically followed up to evaluate recurrence, bleeding and/or death.Time-to-event analysis was performed for these outcomes related to evolucion after discharge.Results:3457 confirmed VTD episodes were included for the analysis (1985 DVT, 930 PE and 542 DVT + DVT), corresponding to 3157 patients. Most were elderly, the median age was 68 years (SD 16) with a predominance of women 57% (1955). Most frequent predisposing factors were immobility (45%), active cancer (35%), recent surgery (33%), obesity (26%), recent hospitalization (22%) and previous VTE (21%).One fourth of pulmonary embolism had sPESI 0 points. Mortality, recurrence and bleeding rates within 30 days were 14%, 10% and 5% respectively.Conclusions: High proportion of VTD require hospitalization for their management, even PE with low sPESI. Mortality and complication remain elevated. We encourage the development and maintenance of more VTD registries in Latin America, to fully understand local characteristics of this disease.