REDOX IMBALANCE IN LATERAL GENICULATE NUCLEUS IN AN EXPERIMENTAL GLAUCOMA MODEL

CLAUDIA G. REIDES; HVOZDA ARANA, AILEN G.; LASAGNI VITAR, ROMINA M.; JANEZIC, NATASHA S.; LERNER, S. FABIAN; LLESUY, SUSANA F.; FERREIRA, SANDRA M.

Mar del Plata

Congreso; Reunión de la Sociedad Argentina de Investigaciones Clínicas (SAIC); 2019

Antioxidant system is needed to respond to oxidative insult and to maintain redox homeostasis. Redox imbalance plays a significant role in development of glaucoma. The aim of this work was to evaluate the changes that occur in redox imbalance in lateral geniculate nucleus (LGN) of rats subjected to an experimental glaucoma model. Wistar rats (3 months) were divided in two groups (n= 12): glaucoma in which rats were operated by cauterized two of the episcleral veins (G) and control which received a sham procedure (C)(CICUAL FFYB 3314). Seven days after surgery rats were euthanized, brains were removed and LGN were separated. The markers evaluated were: thiobarbituric acid reactive substances (TBARS), protein carbonylation (PC), nitrites levels (NO), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), thioredoxin reductase (TrxR), total reactive antioxidant potential (TRAP) and glutathione (GSH). Comparing G to C: there were an increase in TBARS (34 %, p