TRIPLE-NEGATIVE BREAST CANCER SKEWS B CELL RESPONSE TOWARDS AN IMMATURE AND IMMUNOSUPPRESSIVE PHENOTYPE

SARBIA N; MANSELLE COCCO MN; MAHMOUD YD; MARTÍNEZ ALLO VC; GATTO SG; MORALES RM; REVALE S; RABINOVICH GA; SALATINO M*; TOSCANO MA*

BUENOS AIRES

Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2020; 2020

SAIC/SAI/SAFIS

Triple-negative breast cancer (TNBC) is one of the breast tumor subtypes with the worst prognosis due to its aggressiveness and the scarce treatment options available. B lymphocytes are arising as important players in antitumor immunity, but the way in which breast tumors can affect B cell development in distant organs and their resulting effector functions have not been fully addressed. We found that immature proB cells were enriched in the tumor microenvironmentof TNBC patients compared to healthy breast tissue, HER2-overexpressed, luminal A, and luminal B breast tumors (p