Resveratrol prevents oxaliplatin-induced neuronal injury and allodynia through anti-oxidant and anti-inflammatory mechanisms

M. D. RECALDE; S.L. GONZALEZ; M.F. CORONEL

Villa Carlos paz, Córdoba

Congreso; XXXIV Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias; 2019

Sociedad Argentina de Investigación en Neurociencias

Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a frequent and devastating side effect of cancer therapy. No preventative strategies are available. We evaluated the use of resveratrol (RESV) in the prevention of CIPNP and the mechanisms involved. Male rats were injected with oxaliplatin (OXA) and received RESV or vehicle in their drinking water, starting before chemotherapy and thereafter. Mechanical and thermal allodynia and the expression of anti-oxidant, pro-inflammatory and neuronal injury markers were evaluated at lumbar dorsal root ganglia (DRGs) and spinal cord (SC). Animals receiving OXA showed a decrease in paw mechanical and thermal thresholds (p0.05 at every time point). A significant increase in the mRNA levels of ATF3, NFkb and TNF was detected in the DRGs of OXA animals, while an upregulation of c-fos, Nrf2, NFkb and TNFwas observed in the dorsal SC (p0.05 vs CTL in all cases), while inducing an increase in the expression of Nrf2 and SIRT1 (p