BECAS
DI GRESIA Gabriel Edgardo
congresos y reuniones científicas
Título:
Data mining to find new potential inhibitors of endocannabinoid metabolism.
Autor/es:
EXEQUIEL O. J. PORTA; RENZO CARLUCCI; GABRIEL DI GRESIA; BRUNO HERNÁNDEZ CRAVERO; GUILLERMO R. LABADIE
Lugar:
Buzios
Reunión:
Simposio; 8th Brazilian Symposium on Medicinal Chemistry; 2016
Institución organizadora:
BrazMedChem
Resumen:
The endocannabinoid signaling system regulates diverse physiologic processes and has attracted considerable attention as a potential pharmaceutical target for treating diseases, such as chronic pain, anxiety/depression, and metabolic disorders. The principal ligands of the endocannabinoid system are the lipid transmitters N-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), which activate the two major cannabinoid receptors, CB1 and CB2. Anandamide and 2-AG signaling pathways in the nervous system are terminated by enzymatic hydrolysis mediated primarily by the serine hydrolases fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively.
