DEVELOPMENT OF INTERNAL STATES OF BRAIN ACTIVITY

RODRIGUEZ M; MURER MG

Cordoba

Congreso; I reunion Conjunta de Neurociencia; 2009

Sociedad Argentina de Investigación en Neurociencia

Spontaneous brain activity, which represents 60-80 of brain energy expenditure at rest, is evident as stereotypic oscillations in local field potential coordinated in time and space. It depends on the history of activity during the execution of tasks and affects the behavioral responses to stimuli, regulating information flow and synaptic efficacy, and reflecting the functional architecture of underlying neural circuits. Different internal brain states are defined by the degree of synchronization of such networks, arising as periodic oscillations hierarchically organized in frequency bands. During sleep, recapitulation of neural activity patterns experienced during wake would aid the consolidation of memories or habits. Under anesthesia, it is possible to obtain activity states similar to different states of the wakesleep cycle. Here, we analyze the development of internal brain states in anesthetized rats, using the power of characteristic frequency bands in spectrograms of local field potential recordings from prefrontal cortex and hippocampus. The results suggest that, considering the main states, the prefrontal slow wave / hippocampal large irregular activity state is well developed in pre-adolescents and adults, while the prefrontal activation / hippocampal thetha rhythm state is only well developed in the latter. The next step will be the chronic implant of electrodes in both groups of rats to confirm these results in freely moving animals. ULTIMO_