UNDERSTANDING THE MECHANISM OF SILVER NANOPARTICLE TOXICITY

GARCÉS MARIANA; MAGNANI NATALIA; CALABRÓ VALERIA; MARCHINI TIMOTEO; CACERES LOURDES; SALGUEIRO JIMENA; GALDOPORPORA JUAN; ZUBILLAGA MARCELA; MORETTON MARCELA; DESIMONE MARTÍN; PECORELLI ALESSANDRA; SILVIA ALVAREZ; VALACCHI GIUSEPPE; EVELSON PABLO

Congreso; SFRRE 2019. Redox homeostasis: From signalling to damage; 2019

The development of silver nanoparticles (AgNP) applications increased the concern about their toxicity. As the respiratory system in one of the exposure routes, the aim of this study was to evaluate the AgNP harmful effects developed in lung. AgNP were able to cleave H2O2 leading to OH? production. In A549 cells exposed to 2.5 μg/mL AgNP a decreased mitochondrial basal and maximal respiration (p