Pediatric glucose regulation without pre-meal insulin boluses: an approach based on switched control and time-varying IOB constraints

FUSHIMI, EMILIA; SERAFINI, CECILIA; SANCHEZ PEÑA, RICARDO SALVADOR; DE BATTISTA, HERNÁN; FABRICIO GARELLI

Berlin

Congreso; IFAC World Congress; 2020

International Federation of Automatic Control (IFAC)

Articial pancreas (AP) systems have shown to improve glucose regulation in type 1diabetes (T1D) patients. However, full closed-loop performance remains a challenge particularlyin children and adolescents, since these age groups often present the worst glycemic control. Inthis work, a new algorithm based on switched control and time-varying insulin-on-board (IOB)constraints is presented (ARGAE). This method is a combination of ideas from the previouslyintroduced Automatic Regulation of Glucose (ARG) algorithm, which features no pre-mealinsulin boluses, and the Amplitude Enable (AE) mode, which allows the controller to actmore aggressively at the beginning of meal intake without risking postprandial hypoglycemia.The proposed control strategy is evaluated in silico and its performance contrasted with theARG algorithm in the pediatric population. Results show that the ARGAE presents improvedperformance compared to the ARG algorithm even in presence of misclassied meals. Thus,future in vivo testing will involve the AE conguration.