MEDICINAL PLANTS FROM MENDOZA AMELIORATE INTESTINAL PERMEABILITY EX VIVO

ISABEL M. QUESADA; CARLOS GONZÁLEZ QUILÉN; MAYRA VILCA; DEPAOLA MATILDE; CARLOS GAMMARRA-LUQUES; XIMENA TERRA; CLAUDIA CASTRO

San Luis

Congreso; XXXVI Reunión Científica Anual de la SBCuyo; 2019

Obesity is associated with impaired intestinal epithelial barrier function and an altered microbiome, which contribute to host systemic inflammation. Tessaria abisinthioides (Ta) and Prosopis strombulífera (Ps) are native plants from South-America with reported ethnopharmacological uses. There is no evidence of intestinal health promoting effects of Ta and Ps. Thus, the aim of this study was to analyze the protective effect of Ta and Ps in pig intestinal inflammation induced by Dextran Sulfate Sodium (DSS) ex vivo. Intestinal permeability was evaluated in an ex vivo Ussing chamber system (Dipl.-Ing. Muβler Scientific Instruments, Aachen, Germany) by measuring transepithelial electrical resistance (TEER). Ex vivo Ussing chamber assays showed a 70% reduction in TEER in proximal colons of pigs when they were exposed to 8% DSS during 1 hour (P