PRENATAL AND POSTNATAL ZINC DEFICIENCY EXACERBATES THE CARDIOVASCULAR EFFECTS OF ANGIOTENSIN II

NICOLÁS ESTEBAN CIANCIO DEL GIUDICE; NATALIA GOBETTO; FACUNDO MENDES GARRIDO; MELISA SARAVIA; SOFIA BANDIERA; DAMIÁN ARIEL SORIA; FRANKLIN ECHEVERRÍA PAREDES; AGUSTINA CASTAÑÓN; JORGE TOBLII; ROSANA ELESGARAY; CAROLINA CANIFFI; ANALÍA TOMAT; CRISTINA ARRANZ

Buenos Aires

Congreso; REUNIÓN CONJUNTA DE SOCIEDADES DE BIOCIENCIAS; 2017

Zinc deficiency (ZD) programs cardiovascular alterations in malerats.Objective: To evaluate the cardiovascular effects of chronic infusionwith angiotensin II (AII) in male rats subjected to prenatal andpostnatal ZD.Method:Wistar rats fed during pregnancy until weaning control(C,30ppm) or zinc deficient (B,8ppm) diets. At weaning, C male offspringcontinued on C diet (CC) and B offspring received B or Cdiets for 60 days (BB, BC). At 67 days of life, subcutaneous infusionsof AII (65 ng/min/rat) or 0.9% NaCl were administered to animalsfor 14 days using osmotic pumps (Model 2002,Alzet,Palo Alto,USA).Systolic blood pressure (SBP,tail-cuff method,mmHg); cardiac(C) and aortic(A) inflammatory markers (TNFα,IL-6;IHQ; %areamarked/total tissue area); perivascular collagen/lumen area(C/L)and media/lumen area(M/L) of A and C arteries (sirius red staining)were determined at 81 days. ANOVA, Bonferroni post-hoc test(n=6/group,αp