"Advances on bio-nanomaterials based on silica and magnetic targeting"

MARIELA A. AGOTEGARAY

Mar del Plata

Congreso; LXIV Reunión Anual de la Sociedad Argentina de Investigación Clínica, IX Reunión Anual de la Sociedad Argentina de Nanomedicinas (NANOMED-Ar); 2019

Conventional treatments for various pathologies currently find limitations related to the low bioavailability of drugs used in the blank site and the adverse effects associated with them. Nanotechnology allows us to create platforms with biocompatible materials for anchoring drugs and biomolecules that can target the specific organ or tissue. Silica nanomaterials provide a versatile surface, added to the fact that from the implementation of specific synthesis methods, self-luminescent materials can be achieved. Thus, it is possible the conjugation in a same material of high value theranostic properties for applications not only in biomedicine but also in the field of research to elucidate the mechanisms by which nanomaterials enter the cell and are metabolized.Another tool for addressing nanomaterials to specific sites in the body is the development magnetic nanoparticles. They consist of an iron oxide core with superparamagnetic properties coated with biocompatible materials that allow the incorporation of drugs. The application of an external magnetic field allows to concentrate the nanoparticles at the desired site. The main pathologies to which we apply this nanotechnology in our laboratory are based on inflammatory, tumor and bone disease. We have developed various platforms of silica and magnetic nanoparticles evaluating the effect of biocompatible coatings and their physicochemical properties. We perform studies on biocompatibility in vitro on vascular and bone cells and on in vivo invertebrate models such as C. elegans as well as on murine mammalian models, achieving magnetic in vivo targeting to bone system in mice. In this way, the great applicability of these nanosystems in the biomedical field is demonstrated in order to improve the conventional therapies of different pathologies with great social impact.