Current practice and resource use associated with treatment of venous thromboembolism disease in Social Security sector of Argentina

ALBAYTERO MN; GLANCSZPIGEL M; CERESETTO JM; GANDARA E; MAC MULLEN M; CANO L; COVINI C; ELGART J

Bogota

Congreso; ISPOR 7th Latin America Conference; 2019

International Society for Pharmacoeconomics and outcomes research

OBJECTIVES: To describe treatment patterns and healthcare resource utilization associated with venous thromboembolic (VTE) disease [deep venous thrombosis (DVT) and pulmonary embolism (PE)] in Argentina. METHODS: Clinical practice (CP) for management of VTE was investigated through a two-round Delphi panel. A questionnaire to define therapeutic pathways and quantify the healthcare resource utilization was developed based on CP guidelines. 13 VTE experts performed the questionnaire in the 1st round. In 2nd round, each participant could see where his/her answer fit within the group average, and accordingly decided if he/she wanted to change the answers. RESULTS: Expert answers stipulated that 56.9% of patients with suspected DVT would classify as probable DVT and perform ultrasound test to confirm diagnosis (Positive 49.6%). Among patients with an unlikely DVT 47.3% would perform a D-dimer test. 34.6% of patients screened for a suspected DVT would have a confirmed diagnose. Regarding patients with suspected PE, 88.8% would be clinically stable and 56.2% classified as probable PE. 95.6% use tomography angiogram for diagnosis. All patients with unlikely PE perform a D-dimer test. 95.1% of patients have not contraindication for anticoagulant treatment. DVT treatment: 61.2% would receive outpatient treatment while 38.8% would be hospitalized. 51.6% would be treated with direct oral anticoagulants (DOACs) and 47.9% use low molecular weight heparin + vitamin K antagonist (LMWH+VKA). Patients treated with LMWH+VKA would have longer inpatient stay than those treated with DOACs (5.6 vs 3.4 days). PE treatment: Patients with high (8.2%) and intermediate (42.2%) clinical risk would be hospitalized. 70.8% of patients with low risk PE would receive outpatient treatment. Most patients with intermediate or low risk of PE would be treated with LMWH+VKA (68.5%) or DOACs (31.5%).CONCLUSIONS: These results help increase our understanding of current practices and healthcare resource utilization associated with the treatment of VTE in Argentina.