ketorolac-tromethamine contained in LP-SBA-15 host as a drug release system

JORGELINA CUSSA; ANTONELA M. PRADOS; JULIANA M. JUÁREZ; M. B. GÓMEZ COSTA; OSCAR A. ANUNZIATA

Perth

Congreso; 19th International Zeolite Conference IZC 2019; 2019

IZC

KETO/LP-SBA-15 composite was synthesized. The material synthesis and loading of KETO into LPSBA-15 pores were successful. We obtained promising results for controlled drug release using the novel LP-SBA-15 material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The best model to fit experimental data was Ritger- Peppas equation.In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of LP-SBA-15 containing KETO.The release of KETO contained in LP-SBA-15 can offer significant improve in controlled drug reléase and enhance a good analgesia effect.