ACTION OF FLAVONOIDS AGAINST TRYPANOSOMA CRUZIEPIMASTIGOTES

CANO R; BARRERA P; CIFUENTES D; SOSA MA; LOZANO E

Buenos Aires

Congreso; NPND4t Scientific Meeting of the Research Network Natural Products against Neglected Diseases; 2018

Trypanosoma cruzi is a monoflagellate parasite that causes Chagas disease. When T. cruzi is grown in liquid medium is mostly found as a non infective (proliferative) stage epimastigote, and with a low percentage of the infective tripomastigote. Natural and synthetic compounds have been used against the parasite, although their use is restricted because the side cytotoxic effects on the hosts. Three new flavonoids, Salvigenin (SVG) (fig.1, A), Xantomicrol (XML) (fig.1, B) and Apigenin (AGN) (fig.1, C), the first two purified from Baccharis scandens and the last of Larrea divaricata, exhibited antiproliferative effect on epimastigote form in cultures. In addition, mitochondrial activity and ROS generation were observed in T. cruzi epimastigotes.